The Importance of Vitamin B6

by lydia on January 2, 2013

First off, I’d like to start this article by stating that I believe in consuming nutrients primarily through real food that is properly prepared or raised. I also believe it is important not to isolate nutrients from others as all nutrients work together synergistically. That said, some nutrients are often more critical to consider taking separately in this day and age due to foods being processed thereby stripping away certain nutrients.  Additionally, the modern American just does not consume enough of certain nutrients in their diet. Let’s take a deeper look at Vitamin B6 and see what role it plays in our overall health.

Vitamin B6 (Pyridoxine)

B6 is involved in more bodily functions than any other nutrient, affecting both physical and mental health. B6 is required for the proper absorption of B12 and the production of HCl. It acts as a coenzyme in the breakdown and utilization of carbohydrates, fats and proteins. It must be present for the production of antibodies and red blood cells. Vitamin B6 (pyridoxine and pyridoxal-5-phosphate, PHP) is an important co-enzyme for many beginning steps in metabolism for many amino acids, as well as the central nervous system. The CNS is where B6 supports the production of GABA (the happy amino acid). B6 converts tryptophan to niacin and arachidonic acid to prostaglandin E2. Arachidonic acid is found in butter, which also converts to GABA.

B6 is also important in facilitating the release of glycogen from the liver and muscles. It helps to produce antibodies and red blood cells, as well as in the synthesis of RNA and DNA. B6 helps to regulate fluid balance in the body by maintaining the balance of sodium and potassium. B6 is needed to maintain a normal intracellular magnesium level, also important for these functions. Vitamin B6 is a synergist to magnesium and zinc. The neurotransmitters norepinephrine and acetylcholine and the allergy regulator histamine all depend on P5P (the active coenzyme form of B6) in their metabolism.

The brain needs B6 to convert tryptophan to serotonin as well. Many amino acid reactions depend on B6 to carry the amino acids into the blood and from the blood into the cells. B6 is also a key link in the utilization of EFA’s as it is a necessary co-factor for essential fatty acid metabolism, particularly the conversion of ALA to EPA and DHA.

Also, studies have shown that B6 found mostly in animal products, contributes to the proper functioning of over 100 enzymes. B6 and zinc are both needed for the production of pancreatic enzymes and hydrochloric acid, they both also create serotonin and other neurotransmitters in the brain. B6 can be produced by the intestinal bacteria. So attempts to increase lactic acid bacteria in the gut, through properly fermented vegetables or probiotics, helps to improve the synthesis of B6. This in turn promotes the production of B3 from the amino acid tryptophan. See how all these nutrients work together?!

B6 also is connected to hormone balance in women. It is readily absorbed from the small intestine and used throughout the body in a vast array of functions. The need for B6 is very high during pregnancy. It is important for maintaining the mother’s hormonal and fluid balance and for the baby’s developing central nervous system, (this is quite possibly why traditional cultures encouraged the consumption of fish roe and raw organ meats to pregnant moms, as these foods are high in B6, and of course a whole host of other nutrients).

B6 helps with estrogen metabolism, by helping to reduce tissue hypersensitivity to estrogen. This is important for woman when the excess hormones need to be conjugated back out of the body, due to hormones in meats, birth control or supplemental estrogen. For that reason, B6 can be helpful with breast tenderness during the menstrual cycle. A B6 deficiency may explain why there may be exaggerated symptoms of estrogen dominance with normal or slightly increased estrogen levels. It may not be the level of estrogen causing estrogen excess symptoms, but rather the exaggerated response that causes estrogen excess symptoms and patterns. (photo credit)

Fish Roe

‘B6 has synergistic beneficial effects on the immune system and sugar metabolism via different pathways. Studies show that a vitamin B6 deficiency can decrease antibody production and suppress the immune response. B6 participates in the maintenance of glutathione status (as a cofactor for glutathione reductase.) It is shown that its deficiency can reduce cell numbers in lymphoid tissues and cause functional abnormalities in the cell mediated immune response. Vitamin B6 is important in hemoglobin synthesis and increases the amount of oxygen carried by hemoglobin. B6 participates in sugar metabolism and helps maintain blood sugar within a normal range.’ (source: Why Do I Still Have Thyroid Symptoms, When My Lab Tests Are Normal?)

B6 Indications:

  • general immune support
  • Asthma
  • Carpel Tunnel Symdrome
  • Diabetes and Heart Support
  • Joint Pain
  • Trigger Finger
  • Sensitivity to MSG
  • Chemical allergies and sensitivities
  • burning or tingling extremeties
  • healing wounds
  • edema
  • gluten intolerance
  • PMS and breast tenderness
  • birth control/oral contraceptives – deplete B6, will likely need B6 for life after being on these
  • prevents morning sickness

Signs/Symptoms of B6 Deficiency:

  • low blood sugar/poor glucose tolerance
  • water retention during pregnancy
  • cracks around the mouth and eyes
  • numbness and cramps in the arms and legs
  • slow learning
  • visual disturbance
  • sore tongue
  • hypochlorhydria (low stomach acid)
  • neuritis
  • arthritis
  • increase in urination
  • gestational diabetes (frequently resolved by taking 50 mg of B6 in P-5-P form per day).
  • excess estrogen
  • menstrual problems
  • calcium retention and excretion of magnesium
  • inability to remember dreams
  • sensitivity to bright light
  • history of birth problems like spontaneous abortions or fetal abnormality
  • use of antidepressants increases the need for B6
  • use of bronchodilators, antibiotics, diuretics, hormone replacement
  • a diet high in refined carbohydrates depletes B6
  • seizures
  • mental retardation

Clearly, the importance of this nutrient is vast within the human body. It is also a synergist to magnesium and zinc. Vitamin C and Potassium are needed for B6 assimilation. The pyridoxal-5-phosphate form is the naturally occurring form of B6 and is more biologically available than the synthetic form, pyridoxine HCl.  For food sources of BB and how to supplement (if necessary) read this post here.

Are you ready to take action to improve your overall health? Get a hair tissue mineral analysis done. This test will let you know your exact mineral status, as well as gain information about toxic minerals and heavy metal levels. Intracellular sodium, calcium, magnesium and potassium and their ratios are important in determining your overall health. You can also determine if you are effectively digesting protein, find out your water and acid-base balance, energy production, thyroid and adrenal function and a whole host of other health problems besides. Learn what is going on with your individual biochemistry so you can begin to correct and reverse health issues today!


[Sources: Biotics Research, Tuesday Minute; Clinical Reference Guide for Biotics Research; Nourishing Traditions. Sally Fallon; Primal Body- Primal Mind. Nora Gedguadas; Why Do I Still Have Thyroid Symptoms When My Lab Tests Are Normal, Dr. Kharazzian; Magnesium Miracle. Carolyn Dean; The Mood Cure, Julia Ross; Signs and Symptoms: Analysis from a Functional Perspective. Dicken Weatherby]




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Moon January 4, 2013 at 11:46 am

Even after resolving my B12 deficiency, I was still having numbness and tingling in my feet almost daily and my doc suggested adding 50mg of B6 at bedtime. The numbness went away (unless I drink alcohol of any kind, so I just don’t do that either.) But I just had my B6 level checked the other day and it is at 70 which the person seemed to think is an excess. I wonder if I should drop down to 25mgs. I look forward to your next article.

Terri January 7, 2013 at 11:16 am

I have been taking B6 supplements since I stopped taking birth control pills almost 30 years ago. I believe taking them caused a deficiency that I have never reversed. I would like to be able to stop taking supplements, and this gives me some places to start increasing B6 in my diet. I look forward to your next post.

CamGirl October 18, 2016 at 1:51 pm

I love the brainy-ness of this explanation! So many sites keep their explanations too simple. It is great to see the connection B6 has with feel-good chemicals in our body like serotonin and GABA. This is one step closer to heal my nervous system that has been compromised from my tapped out adrenals and increased cortisol.

I have depleted my system of progesterone from bodily and emotional stress, from becoming dehydrated since moving to the South states and trying a vegan cleansing diet (which helped initially- but should not be done long-term). I am having a lot to heal from and since 100mg B6 is included in my Vitex capsule supplement I set out to make sure it was okay taking that much. It sounds like B6 will help my low blood sugar issues which is a side effect from prolonged low levels of progesterone. I have been taking Biotin as it is supposed to help with that as well. Thank you very much! I am ecstatic to be benefiting from this 3 years later! God bless!

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